Tbio RPP25 Ribonuclease P protein subunit p25

Protein Summary

Description

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA.

Uniprot Accession IDs

• Q9BUL9
• D3DW70
• Q9NX88
• RNase P protein subunit p25

Gene Name

• RPP25

Ensembl ID

• ENST00000322177
• ENSP00000317691
• ENSG00000178718

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
transcription factor binding site profile	0.9
histone modification site profile	0.8
PubMedID	0.75
tissue sample	0.68

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Ribonuclease P Protein Subunit P25

DTO Classes

Protein / Enzyme / Nuclease / Ribonuclease P Protein Subunit P25

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.13   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.13   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0