Protein Summary
Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]
- ENST00000313341
- ENSP00000317333
- ENSG00000178403
- ATOH4
- BHLHA8
- NGN2
- NGN2
- Atoh4
- ngn-2
- Math4A
- bHLHa8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
biological process | 0.74 | ||
transcription factor binding site profile | 0.68 | ||
histone modification site profile | 0.65 | ||
PubMedID | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 251.58 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 331 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 251.58 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 331 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0