FUT6
Alpha-(1,3)-fucosyltransferase 6
Protein Summary
Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates. The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000286955
- ENSP00000286955
- ENSG00000156413
- ENST00000318336
- ENSP00000313398
- ENST00000524754
- ENSP00000431708
- ENST00000527106
- ENSP00000432954
- ENST00000592563
- ENSP00000466016
- FCT3A
- FT1A
- FCT3A
- Fuc-TVI
- FucT-VI
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.95 | ||
cell type or tissue | 0.81 | ||
cellular component | 0.7 | ||
cell line | 0.54 | ||
small molecule perturbation | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 78.71 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 232 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 78.71 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 232 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0