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Tbio
MADD
MAP kinase-activating death domain protein

Protein Summary
Description
Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311027
  • ENSP00000310933
  • ENSG00000110514
  • ENST00000349238
  • ENSP00000304505
  • ENST00000395336
  • ENSP00000378745
  • ENST00000395344
  • ENSP00000378753
  • ENST00000402192
  • ENSP00000384287
  • ENST00000402799
  • ENSP00000385585
  • ENST00000406482
  • ENSP00000384435
  • ENST00000407859
  • ENSP00000384204

Symbol
  • DENN
  • IG20
  • KIAA0358
  • DENN
  • IG20
  • RAB3GEP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor
0.86
kinase perturbation
0.84
transcription factor binding site profile
0.79
cell line
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.92   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.92   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0