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Tbio
CSHL1
Chorionic somatomammotropin hormone-like 1

Protein Summary
Description
May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. This particular family member is expressed in placental villi, although it was originally thought to be a pseudogene. In fact, alternative splicing suggests that the majority of the transcripts would be unable to express a secreted protein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by Re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309894
  • ENSP00000309524
  • ENSG00000204414
  • ENST00000346606
  • ENSP00000316360
  • ENST00000438387
  • ENSP00000402632

Symbol
  • CSHP1
  • CSL
  • CSL
  • CS-5
  • GHB4
  • CSHP1
  • hCS-L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
gene perturbation
0.71
cell line
0.68
small molecule perturbation
0.66
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.06   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.06   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0