Tbio HLTF Helicase-like transcription factor

Protein Summary

Description

Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14527
• D3DNH3
• Q14536
• Q16051
• Q7KYJ6
• Q86YA5
• Q92652
• Q96KM9

Gene Name

• HLTF

Ensembl ID

• ENST00000310053
• ENSP00000308944
• ENSG00000071794
• ENST00000392912
• ENSP00000376644
• ENST00000494055
• ENSP00000420429

Symbol

• HIP116A
• RNF80
• SMARCA3
• SNF2L3
• ZBU1
• ZBU1
• HLTF1
• RNF80
• HIP116
• SNF2L3
• HIP116A
• SMARCA3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein complex	1
protein domain	0.99
interacting protein	0.94
virus perturbation	0.9

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.86   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 283   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.86   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0