Tbio TLR10 Toll-like receptor 10

Protein Summary

Description

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• Q9BXR5
• A8K7L1
• B3Y668
• D1CS21
• D1CS22
• Q32MI7
• Q32MI8
• Q5FWG4
• Q6UXL3

Gene Name

• TLR10

Ensembl ID

• ENST00000308973
• ENSP00000308925
• ENSG00000174123
• ENST00000361424
• ENSP00000354459
• ENST00000506111
• ENSP00000421483
• ENST00000508334
• ENSP00000424923
• ENST00000613579
• ENSP00000478206
• ENST00000622002
• ENSP00000478985

Symbol

• CD290

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.97
protein domain	0.73
tissue sample	0.63
phenotype	0.6
biological term	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.65   (req: < 5)

Gene RIFs: 83   (req: <= 3)

Antibodies: 378   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.65   (req: >= 5)

Gene RIFs: 83   (req: > 3)

Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0