Tbio KRT74 Keratin, type II cytoskeletal 74

Protein Summary

Description

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]

Uniprot Accession IDs

• Q7RTS7
• B5MD61
• Q86Y45

Gene Name

• KRT74

Ensembl ID

• ENST00000305620
• ENSP00000307240
• ENSG00000170484

Symbol

• K6IRS4
• KB37
• KRT5C
• KRT6IRS4
• ADWH
• HTSS2
• HYPT3
• KRT5C
• K6IRS4
• KRT6IRS4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.58
cellular component	0.55
cell line	0.51
phenotype	0.44
chemical	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.48   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.48   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0