TBCA
Tubulin-specific chaperone A
Protein Summary
Tubulin-folding protein; involved in the early step of the tubulin folding pathway. The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
- ENST00000306388
- ENSP00000306362
- ENSG00000171530
- ENST00000380377
- ENSP00000369736
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.88 | ||
tissue sample | 0.69 | ||
disease perturbation | 0.68 | ||
transcription factor binding site profile | 0.68 | ||
transcription factor perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.09 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 242 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.09 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 242 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0