Tbio RPAP1 RNA polymerase II-associated protein 1

Protein Summary

Description

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q9BWH6
• Q9H9I2
• Q9NSQ5
• Q9P2E4
• Q9UFS7

Gene Name

• RPAP1

Ensembl ID

• ENST00000304330
• ENSP00000306123
• ENSG00000103932
• ENST00000562303
• ENSP00000455363

Symbol

• KIAA1403

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
tissue sample	0.8
transcription factor binding site profile	0.74
cell type or tissue	0.7
small molecule perturbation	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 115   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0