Tbio CEP89 Centrosomal protein of 89 kDa

Protein Summary

Description

Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity.

Uniprot Accession IDs

• Q96ST8
• B9EGA6
• Q8N5J8
• Cep89

Gene Name

• CEP89

Ensembl ID

• ENST00000305768
• ENSP00000306105
• ENSG00000121289

Symbol

• CCDC123
• CEP123
• CCDC123

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
kinase perturbation	0.81
tissue	0.77
transcription factor	0.67
cellular component	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.76   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.76   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0