Tbio UTF1 Undifferentiated embryonic cell transcription factor 1

Protein Summary

Description

Acts as a transcriptional coactivator of ATF2. The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• Q5T230
• O75833
• Q6J1H3

Gene Name

• UTF1

Ensembl ID

• ENST00000304477
• ENSP00000305906
• ENSG00000171794

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.68
PubMedID	0.67
gene perturbation	0.65
cell type or tissue	0.63
biological process	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.28   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 236   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.28   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0