Tbio FUT3 Galactoside 3(4)-L-fucosyltransferase

Protein Summary

Description

May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links. The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P21217
• B5U7U9
• B5U7V0
• Q32NE7
• Q99448
• Q99449

Gene Name

• FUT3

Ensembl ID

• ENST00000303225
• ENSP00000305603
• ENSG00000171124
• ENST00000458379
• ENSP00000416443
• ENST00000589620
• ENSP00000465804
• ENST00000589918
• ENSP00000468123

Symbol

• FT3B
• LE
• LE
• Les
• FT3B
• CD174
• FucT-III

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.78
virus perturbation	0.68
biological term	0.59
disease	0.59
pathway	0.59

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Galactoside 3(4)-l-fucosyltransferase

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Galactoside 3(4)-l-fucosyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.21   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 415   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.21   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 415   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0