Tbio TXNDC2 Thioredoxin domain-containing protein 2

Protein Summary

Description

Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

Uniprot Accession IDs

• Q86VQ3
• A5YM73
• Q8N7U4
• Q96RX3
• Q9H0L8

Gene Name

• TXNDC2

Ensembl ID

• ENST00000306084
• ENSP00000304908
• ENSG00000168454
• ENST00000357775
• ENSP00000350419
• ENST00000611534
• ENSP00000483261

Symbol

• SPTRX
• SPTRX1
• SPTRX
• SPTRX1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.74
cellular component	0.64
cell type or tissue	0.63
protein domain	0.58
molecular function	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.17   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 24   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.17   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0