Tbio PYDC1 Pyrin domain-containing protein 1

Protein Summary

Description

Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

Uniprot Accession IDs

• Q8WXC3
• B2R8L4
• Q8NFP8

Gene Name

• PYDC1

Ensembl ID

• ENST00000302964
• ENSP00000304336
• ENSG00000169900

Symbol

• ASC2
• ASCI
• POP1
• PYC1
• ASC2
• POP1
• PYC1
• cPOP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.67
cell line	0.46
tissue sample	0.43
hub protein	0.39
cell type or tissue	0.36

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.87   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.87   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0