Tbio FAM83B Protein FAM83B

Protein Summary

Description

Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.

Uniprot Accession IDs

• Q5T0W9
• Q2M1P3
• Q96DQ2

Gene Name

• FAM83B

Ensembl ID

• ENST00000306858
• ENSP00000304078
• ENSG00000168143

Symbol

• C6orf143
• C6orf143

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.59
cell line	0.57
cell type or tissue	0.55
interacting protein	0.51
drug perturbation	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.66   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 60   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.66   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0