Protein Summary
Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells. The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]
- ENST00000304920
- ENSP00000302924
- ENSG00000172458
- IL-17D
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.78 | ||
histone modification site profile | 0.78 | ||
cell type or tissue | 0.67 | ||
transcription factor binding site profile | 0.55 | ||
transcription factor perturbation | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.34 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 416 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.34 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 416 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0