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Tchem
BCL2L1
Bcl-2-like protein 1

Protein Summary
Description
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). Isoform Bcl-X(S) promotes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307677
  • ENSP00000302564
  • ENSG00000171552
  • ENST00000376055
  • ENSP00000365223
  • ENST00000376062
  • ENSP00000365230

Symbol
  • BCL2L
  • BCLX
  • BCLX
  • BCL2L
  • Bcl-X
  • PPP1R52
  • BCL-XL/S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
transcription factor perturbation
1
biological process
0.99
kinase perturbation
0.99
protein domain
0.99


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4313.36   (req: < 5)
Gene RIFs: 522   (req: <= 3)
Antibodies: 1812   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4313.36   (req: >= 5)
Gene RIFs: 522   (req: > 3)
Antibodies: 1812   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 781
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2