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Tbio
NHLH1
Helix-loop-helix protein 1

Protein Summary
Description
May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302101
  • ENSP00000302189
  • ENSG00000171786

Symbol
  • BHLHA35
  • HEN1
  • HEN1
  • NSCL
  • NSCL1
  • bHLHa35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.67
tissue
0.59
biological process
0.57
tissue sample
0.56
cell type or tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.61   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.61   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0