You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ANTXR1
Anthrax toxin receptor 1

Protein Summary
Description
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode diffe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303714
  • ENSP00000301945
  • ENSG00000169604
  • ENST00000409349
  • ENSP00000386494
  • ENST00000409829
  • ENSP00000387058

Symbol
  • ATR
  • TEM8
  • ATR
  • GAPO
  • TEM8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
transcription factor perturbation
0.88
PubMedID
0.84
ligand (protein) perturbation
0.83
kinase perturbation
0.81


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.31   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 569   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.31   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 569   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0