Protein Summary
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016]
- ENST00000301607
- ENSP00000301607
- ENSG00000167880
- EVPK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.71 | ||
gene perturbation | 0.66 | ||
small molecule perturbation | 0.63 | ||
cell line | 0.55 | ||
tissue sample | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 367.66 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 50 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 367.66 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 50 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0