Tbio CGB3 Choriogonadotropin subunit beta 3

Protein Summary

Description

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P0DN86
• A1A5E0
• B9ZVP5
• P01233
• Q13991
• Q14000
• Q3KPI3
• Q3SY41
• Q8WTT5
• Q8WXL1
• Q8WXL2
• Q8WXL3
• Q8WXL4

Gene Name

• CGB3

Ensembl ID

• ENST00000301408
• ENSP00000301408
• ENSG00000189052
• ENST00000357383
• ENSP00000349954
• ENSG00000104827
• ENST00000448456
• ENSP00000403649
• ENSG00000213030

Symbol

• CGB
• CGB
• CGB5
• CGB7
• CGB8
• hCGB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.76
cell type or tissue	0.63
tissue	0.43
phenotype	0.37
cell line	0.35

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Choriogonadotropin Subunit Beta 3

DTO Classes

Protein / Signaling / Hormone / Choriogonadotropin Subunit Beta 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.66   (req: < 5)

Gene RIFs: 109   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.66   (req: >= 5)

Gene RIFs: 109   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0