Tbio ZNF91 Zinc finger protein 91

Protein Summary

Description

Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777). The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]

Uniprot Accession IDs

• Q05481
• A8K5E1
• B7Z6G6

Gene Name

• ZNF91

Ensembl ID

• ENST00000300619
• ENSP00000300619
• ENSG00000167232
• ENST00000397082
• ENSP00000380272

Symbol

• HPF7
• HTF10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.69
transcription factor binding site profile	0.66
small molecule perturbation	0.61
gene perturbation	0.59
PubMedID	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.83   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.83   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0