Tbio PPP1R16B Protein phosphatase 1 regulatory inhibitor subunit 16B

Protein Summary

Description

Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934). The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• Q96T49
• A2RRR6
• E9PFS8
• O94912
• Q5W9G4
• Q9NQG4

Gene Name

• PPP1R16B

Ensembl ID

• ENST00000299824
• ENSP00000299824
• ENSG00000101445
• ENST00000373331
• ENSP00000362428

Symbol

• ANKRD4
• KIAA0823
• TIMAP
• ANKRD4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.85
transcription factor	0.74
kinase perturbation	0.71
transcription factor binding site profile	0.71
biological process	0.64

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Protein Phosphatase 1 Regulatory Inhibitor Subunit 16b

DTO Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Protein Phosphatase 1 Regulatory Inhibitor Subunit 16b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.14   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.14   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0