Tchem IL15 Interleukin-15

Protein Summary

Description

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P40933
• D3DNZ2
• O00440
• O43512
• Q495Z8
• Q6FGX7
• Q93058
• Q9UBA3
• IL-15

Gene Name

• IL15

Ensembl ID

• ENST00000296545
• ENSP00000296545
• ENSG00000164136
• ENST00000320650
• ENSP00000323505
• ENST00000394159
• ENSP00000377714
• ENST00000477265
• ENSP00000436914
• ENST00000514653
• ENSP00000422271
• ENST00000529613
• ENSP00000435462

Symbol

• IL-15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
PubMedID	0.86
transcription factor perturbation	0.84
histone modification site profile	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2470.25   (req: < 5)

Gene RIFs: 420   (req: <= 3)

Antibodies: 1013   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2470.25   (req: >= 5)

Gene RIFs: 420   (req: > 3)

Antibodies: 1013   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0