Tbio MON1A Vacuolar fusion protein MON1 homolog A

Protein Summary

Description

Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991).

Uniprot Accession IDs

• Q86VX9
• B2RDQ1
• G5E9N1
• Q8NAV7
• Q9BRF3
• X6R3V9

Gene Name

• MON1A

Ensembl ID

• ENST00000296473
• ENSP00000296473
• ENSG00000164077
• ENST00000455683
• ENSP00000404793
• ENST00000642691
• ENSP00000494294
• ENST00000645862
• ENSP00000494452

Symbol

• SAND1
• SAND1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
cellular component	0.78
cell type or tissue	0.65
histone modification site profile	0.6
tissue	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.41   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 151   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.41   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0