Protein Summary
Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Apr 2016]
- ENST00000296444
- ENSP00000296444
- ENSG00000164054
- ENST00000426002
- ENSP00000390388
- ENST00000442747
- ENSP00000408223
- ENST00000443308
- ENSP00000395373
- ENST00000444115
- ENSP00000407957
- ENST00000619810
- ENSP00000484992
- SCOTIN
- SCOTIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 1 | ||
transcription factor perturbation | 0.99 | ||
small molecule perturbation | 0.96 | ||
kinase perturbation | 0.95 | ||
disease perturbation | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.64 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 120 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.64 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 120 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0