Tbio HELQ Helicase POLQ-like

Protein Summary

Description

Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase (PubMed:11751861). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904). HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8TDG4
• Q05DF9
• Q502W9
• Q659B8
• Q6ZQX4
• Q6ZTS4
• Q96EX7

Gene Name

• HELQ

Ensembl ID

• ENST00000295488
• ENSP00000295488
• ENSG00000163312

Symbol

• HEL308
• HEL308

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
molecular function	0.91
transcription factor binding site profile	0.75
tissue sample	0.63
cell type or tissue	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.78   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 56   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.78   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0