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Tbio
ZSWIM2
E3 ubiquitin-protein ligase ZSWIM2

Protein Summary
Description
E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295131
  • ENSP00000295131
  • ENSG00000163012

Symbol
  • ZZZ2
  • MEX
  • ZZZ2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
virus perturbation
0.59
protein domain
0.58
molecular function
0.49
cell line
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.82   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.82   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0