Tbio RBMS1 RNA-binding motif, single-stranded-interacting protein 1

Protein Summary

Description

Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication. This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• P29558
• Q14869
• Q15433
• Q53P46
• Q53QX8
• Q53RG6
• Q8WV20

Gene Name

• RBMS1

Ensembl ID

• ENST00000348849
• ENSP00000294904
• ENSG00000153250

Symbol

• C2orf12
• MSSP
• MSSP1
• SCR2
• YC1
• MSSP
• SCR2
• HCC-4
• MSSP-1
• MSSP-2
• MSSP-3
• C2orf12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.99
virus perturbation	0.97
disease perturbation	0.96
PubMedID	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.28   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 272   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.28   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0