Tbio AQP5 Aquaporin-5

Protein Summary

Description

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P55064
• Q6FGW8
• AQP-5

Gene Name

• AQP5

Ensembl ID

• ENST00000293599
• ENSP00000293599
• ENSG00000161798

Symbol

• PPKB
• AQP-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
cellular component	0.77
gene perturbation	0.77
molecular function	0.67
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Transporter / Aquaporin-5

DTO Classes

Protein / Ion Channel / Other Ion Channel / Aquaporin / Aquaporin-5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 634.2   (req: < 5)

Gene RIFs: 138   (req: <= 3)

Antibodies: 290   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 634.2   (req: >= 5)

Gene RIFs: 138   (req: > 3)

Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0