Tbio TRAPPC10 Trafficking protein particle complex subunit 10

Protein Summary

Description

May play a role in vesicular transport from endoplasmic reticulum to Golgi. The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P48553
• Q3MIR2
• Q86SI7
• Q9UMD4
• Q9Y4L3

Gene Name

• TRAPPC10

Ensembl ID

• ENST00000291574
• ENSP00000291574
• ENSG00000160218
• ENST00000380221
• ENSP00000369570

Symbol

• EHOC1
• TMEM1
• EHOC1
• GT334
• TMEM1
• TRS30
• EHOC-1
• TRS130

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
microRNA	0.75
transcription factor binding site profile	0.7
virus perturbation	0.68
cell type or tissue	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.87   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.87   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0