Tbio RFX5 DNA-binding protein RFX5

Protein Summary

Description

Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P48382
• B7Z848
• D3DV19
• E9PFU4
• Q5VWC3

Gene Name

• RFX5

Ensembl ID

• ENST00000290524
• ENSP00000290524
• ENSG00000143390
• ENST00000368870
• ENSP00000357864
• ENST00000452671
• ENSP00000389130

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
disease perturbation	0.9
histone modification site profile	0.88
protein complex	0.86
interacting protein	0.75

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Dna-binding Protein Rfx5

Protein / Nucleic Acid Binding / Nuclease / Dna-binding Protein Rfx5

Protein / ... / Winged Helix/forkhead Transcription Factor / Dna-binding Protein Rfx5

DTO Classes

Protein / Enzyme / Nuclease / Dna-binding Protein Rfx5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.21   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 276   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.21   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0