Tbio ERCC6L2 DNA excision repair protein ERCC-6-like 2

Protein Summary

Description

May be involved in early DNA damage response. This gene encodes a member of the Snf2 family of helicase-like proteins. The encoded protein may play a role in DNA repair and mitochondrial function. Mutations in this gene have been associated with bone marrow failure syndrome 2. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q5T890
• A4D997
• B2RTP8
• Q49AM9
• Q5T892
• Q8N663
• Q8N9D0
• Q9NPM7

Gene Name

• ERCC6L2

Ensembl ID

• ENST00000288985
• ENSP00000288985
• ENSG00000182150

Symbol

• C9orf102
• RAD26L
• BMFS2
• SR278
• RAD26L
• C9orf102

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
histone modification site profile	0.89
protein domain	0.85
transcription factor binding site profile	0.83
tissue	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.91   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 154   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.91   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0