KAT6B
Histone acetyltransferase KAT6B
Protein Summary
Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
- ENST00000287239
- ENSP00000287239
- ENSG00000156650
- ENST00000372711
- ENSP00000361796
- ENST00000372714
- ENSP00000361799
- ENST00000372724
- ENSP00000361809
- ENST00000372725
- ENSP00000361810
- ENST00000628038
- ENSP00000485896
- ENSG00000281813
- ENST00000628523
- ENSP00000487238
- ENST00000629233
- ENSP00000487219
- ENST00000629879
- ENSP00000486731
- ENST00000630001
- ENSP00000486595
- ENST00000647630
- ENSP00000497352
- ENST00000648605
- ENSP00000497718
- ENST00000648725
- ENSP00000497841
- ENST00000648892
- ENSP00000497048
- ENST00000649006
- ENSP00000498139
- ENST00000649463
- ENSP00000497166
- ENST00000649574
- ENSP00000497416
- ENST00000650575
- ENSP00000497453
- KIAA0383
- MORF
- MOZ2
- MYST4
- qkf
- MORF
- MOZ2
- GTPTS
- MYST4
- ZC2HC6B
- querkopf
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
transcription factor binding site profile | 0.95 | ||
transcription factor perturbation | 0.84 | ||
cell type or tissue | 0.83 | ||
biological process | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 362.28 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 75 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 362.28 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 75 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0