Tbio TXNDC11 Thioredoxin domain-containing protein 11

Protein Summary

Description

May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.

Uniprot Accession IDs

• Q6PKC3
• O95887
• Q6PJA6
• Q8N2Q4
• Q96K45
• Q96K53

Gene Name

• TXNDC11

Ensembl ID

• ENST00000283033
• ENSP00000283033
• ENSG00000153066
• ENST00000356957
• ENSP00000349439

Symbol

• EFP1
• EFP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
transcription factor binding site profile	0.87
virus perturbation	0.72
virus	0.66
cell type or tissue	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.37   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 115   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.37   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0