Tbio PLOD2 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

Protein Summary

Description

Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00469
• B3KWS3
• Q59ED2
• Q8N170

Gene Name

• PLOD2

Ensembl ID

• ENST00000282903
• ENSP00000282903
• ENSG00000152952
• ENST00000360060
• ENSP00000353170
• ENST00000461497
• ENSP00000419354

Symbol

• LH2
• TLH
• BRKS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
interacting protein	0.87
molecular function	0.76
virus perturbation	0.76
PubMedID	0.75

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.17   (req: < 5)

Gene RIFs: 64   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.17   (req: >= 5)

Gene RIFs: 64   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0