Tbio DSC2 Desmocollin-2

Protein Summary

Description

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Accession IDs

• Q02487

Gene Name

• DSC2

Ensembl ID

• ENST00000251081
• ENSP00000251081
• ENSG00000134755
• ENST00000280904
• ENSP00000280904

Symbol

• CDHF2
• DSC3
• DG2
• DSC3
• CDHF2
• ARVD11
• DGII/III

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.98
transcription factor perturbation	0.97
protein domain	0.92
gene perturbation	0.74
cellular component	0.71

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Desmocollin-2

Protein / Cell Adhesion Molecule / Cadherin / Desmocollin-2

DTO Classes

Protein / Cell Adhesion / Cadherin / Desmocollin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.92   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 297   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.92   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0