Tbio LTO1 Protein LTO1 homolog

Protein Summary

Description

The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452). May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674).

Uniprot Accession IDs

• Q8WV07
• B2R4R2
• Q8NFK0

Gene Name

• LTO1

Ensembl ID

• ENST00000279147
• ENSP00000279147
• ENSG00000149716
• ENST00000535657
• ENSP00000446129

Symbol

• ORAOV1
• TAOS1
• CIAB1
• TAOS1
• ORAOV1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
transcription factor	0.72
transcription factor binding site profile	0.7
histone modification site profile	0.66
tissue	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.28   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.28   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0