Tbio PIGT GPI transamidase component PIG-T

Protein Summary

Description

Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q969N2
• B2RND5
• B7Z3N1
• B7Z7I8
• E1P622
• G8JLF5
• Q2NL69
• Q7Z3N7
• Q9BQY7
• Q9BQY8
• Q9UJG6
• Q9Y2Z5

Gene Name

• PIGT

Ensembl ID

• ENST00000279035
• ENSP00000279035
• ENSG00000124155
• ENST00000279036
• ENSP00000279036
• ENST00000372689
• ENSP00000361774
• ENST00000543458
• ENSP00000441577
• ENST00000545755
• ENSP00000443963

Symbol

• NDAP
• PNH2
• CGI-06
• MCAHS3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.83
cell type or tissue	0.8
cellular component	0.8
disease perturbation	0.79
transcription factor binding site profile	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.93   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.93   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0