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Tbio
CAPN5
Calpain-5

Protein Summary
Description
Calcium-regulated non-lysosomal thiol-protease. Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278559
  • ENSP00000278559
  • ENSG00000149260
  • ENST00000529629
  • ENSP00000432332
  • ENST00000531028
  • ENSP00000467244
  • ENST00000648180
  • ENSP00000498132

Symbol
  • NCL3
  • VRNI
  • ADNIV
  • HTRA3
  • nCL-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
kinase perturbation
0.81
disease perturbation
0.79
histone modification site profile
0.76
transcription factor binding site profile
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.08   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.08   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0