Tbio MINDY3 Ubiquitin carboxyl-terminal hydrolase MINDY-3

Protein Summary

Description

Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q9H8M7
• Q5SZ68
• Q5SZ69
• Q5SZ70
• Q6IA40
• Q6P7P0
• Q7Z2S1
• Q8WUF1
• Q9H3I4

Gene Name

• MINDY3

Ensembl ID

• ENST00000277632
• ENSP00000277632
• ENSG00000148481

Symbol

• C10orf97
• CARP
• DERP5
• FAM188A
• CARP
• DERP5
• my042
• MST126
• FAM188A
• MSTP126
• C10orf97

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.25   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 43   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.25   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0