Tbio HAPLN1 Hyaluronan and proteoglycan link protein 1

Protein Summary

Description

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

Uniprot Accession IDs

• P10915
• B2R9A9

Gene Name

• HAPLN1

Ensembl ID

• ENST00000274341
• ENSP00000274341
• ENSG00000145681

Symbol

• CRTL1
• CRT1
• CRTL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
protein domain	0.85
virus perturbation	0.76
transcription factor perturbation	0.74
PubMedID	0.7

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Hyaluronan And Proteoglycan Link Protein 1

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Hyaluronan And Proteoglycan Link Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.33   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 213   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.33   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0