Protein Summary
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.
- ENST00000273963
- ENSP00000273963
- ENSG00000145332
- ENST00000498875
- ENSP00000426451
- ENST00000512111
- ENSP00000424131
- KIAA1378
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.97 | ||
histone modification site profile | 0.8 | ||
kinase perturbation | 0.76 | ||
transcription factor binding site profile | 0.66 | ||
microRNA | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.78 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 90 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.78 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 90 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0