You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ALDH1L1
Cytosolic 10-formyltetrahydrofolate dehydrogenase

Protein Summary
Description
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273450
  • ENSP00000273450
  • ENSG00000144908
  • ENST00000393431
  • ENSP00000377081
  • ENST00000393434
  • ENSP00000377083
  • ENST00000452905
  • ENSP00000395881
  • ENST00000455064
  • ENSP00000414126
  • ENST00000472186
  • ENSP00000420293

Symbol
  • FTHFD
  • FDH
  • FTHFD
  • 10-fTHF
  • 10-FTHFDH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.88
kinase perturbation
0.76
trait
0.75
transcription factor
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.44   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 412   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.44   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 412   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0