Tbio SLC4A3 Anion exchange protein 3

Protein Summary

Description

Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-). The protein encoded by this gene is a plasma membrane anion exchange protein. The encoded protein has been found in brain, heart, kidney, small intestine, and lung. [provided by RefSeq, May 2016]

Uniprot Accession IDs

• P48751
• A6H8L2
• A8K1Q9
• B7ZVX6
• B9EGD1
• Q6YIQ9
• AE 3

Gene Name

• SLC4A3

Ensembl ID

• ENST00000273063
• ENSP00000273063
• ENSG00000114923
• ENST00000317151
• ENSP00000314006
• ENST00000358055
• ENSP00000350756
• ENST00000373760
• ENSP00000362865

Symbol

• AE3
• AE3
• SLC2C
• CAE3/BAE3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
protein domain	0.92
disease perturbation	0.87
transcription factor	0.62
histone modification site profile	0.61

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc4 Family Of Bicarbonate Transporters / Anion Exchangers / Anion Exchange Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.35   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 25   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.35   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0