Tbio REG3G Regenerating islet-derived protein 3-gamma

Protein Summary

Description

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury. This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• Q6UW15
• A8K980
• D6W5J6
• Q3SYE4
• Q3SYE6
• Q6FH18
• REG-3-gamma

Gene Name

• REG3G

Ensembl ID

• ENST00000272324
• ENSP00000272324
• ENSG00000143954
• ENST00000393897
• ENSP00000377475
• ENST00000409471
• ENSP00000387105

Symbol

• PAP1B
• PAP1B
• PAPIB
• PAP IB
• PAP-1B
• UNQ429
• LPPM429
• REG III
• REG-III

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
cell type or tissue	0.88
cell line	0.59
protein domain	0.58
phenotype	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.55   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 228   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.55   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0