Tbio EMP3 Epithelial membrane protein 3

Protein Summary

Description

Probably involved in cell proliferation and cell-cell interactions. The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• P54852
• Q6FH01
• EMP-3

Gene Name

• EMP3

Ensembl ID

• ENST00000270221
• ENSP00000270221
• ENSG00000142227
• ENST00000597279
• ENSP00000469194

Symbol

• YMP
• YMP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
kinase perturbation	0.84
gene perturbation	0.81
small molecule perturbation	0.72
PubMedID	0.68

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Epithelial Membrane Protein 3

DTO Classes

Protein / Cellular Structure / Epithelial Membrane Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.71   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 214   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.71   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0