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Tclin
ERBB3
Receptor tyrosine-protein kinase erbB-3

Protein Summary
Description
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267101
  • ENSP00000267101
  • ENSG00000065361
  • ENST00000411731
  • ENSP00000415753
  • ENST00000415288
  • ENSP00000408340
  • ENST00000551242
  • ENSP00000447510

Symbol
  • HER3
  • HER3
  • FERLK
  • LCCS2
  • ErbB-3
  • c-erbB3
  • erbB3-S
  • MDA-BF-1
  • c-erbB-3
  • p180-ErbB3
  • p45-sErbB3
  • p85-sErbB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.99
transcription factor perturbation
0.98
hub protein
0.97
kinase perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1145.12   (req: < 5)
Gene RIFs: 411   (req: <= 3)
Antibodies: 2081   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1145.12   (req: >= 5)
Gene RIFs: 411   (req: > 3)
Antibodies: 2081   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6