Tbio ASCL1 Achaete-scute homolog 1

Protein Summary

Description

Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P50553
• A8K3C4
• Q9BQ30
• ASH-1

Gene Name

• ASCL1

Ensembl ID

• ENST00000266744
• ENSP00000266744
• ENSG00000139352

Symbol

• ASH1
• BHLHA46
• HASH1
• ASH1
• HASH1
• MASH1
• bHLHa46

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.97
gene perturbation	0.86
PubMedID	0.86
cell line	0.63

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Achaete-scute Homolog 1

Protein / Nucleic Acid Binding / Achaete-scute Homolog 1

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Achaete-scute Homolog 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 473.44   (req: < 5)

Gene RIFs: 90   (req: <= 3)

Antibodies: 486   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 473.44   (req: >= 5)

Gene RIFs: 90   (req: > 3)

Antibodies: 486   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 64

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0